氫分子醫學的新啟示：一些臨床藥物的奇怪作用

 

這個觀點實際上與我去年的文章是類似的，我們去年提出的觀點是內源性氫是一種抗氧化物質，這個文章的觀點是有些糖尿病藥物，可抑制能量物質吸收，有一個明顯的副作用是大腸內產生氣體，這類藥物往往具有器官保護作用。過去一直不明白為什麼這樣。日本學者提出的這個觀點，我是非常同意。過去1年我們課題組多次討論到這個話題。可惜我們沒有把這個觀點形成文章。真的十分可惜。

Hypothesis

Are the effects of 

Yoshihiko Suzuki ^a, Motoaki Sano ^c, , , Kentaro Hayashida ^c, Ikuroh Ohsawa ^a, b, Shigeo Ohta^aand Keiichi Fukuda^c

^a Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

^b The Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

^c Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 April 2009; 

revised 28 May 2009; 

accepted 31 May 2009. 

Available online 8 June 2009. 

α -glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

Abstract

The major side-effect of treatment with α -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H ₂in the gastrointestinal tract. Acarbose, which is an α -glucosidase inhibitor, markedly increased H ₂production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H ₂acts as a unique antioxidant, and that when inhaled or taken orally as H ₂-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.

Keywords: α -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant

Article Outline

1. Introduction

2. Molecular hydrogen (H ₂) acts as a novel antioxidant

3. Unexpected benefit of flatulence caused by α -glucosidase inhibitors

4. Conclusion

Conflict of interest statement

Acknowledgements

References

Corresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.

全文下在這裡

 

 

---

  

台灣氫水實驗室 TEL:0963-210-763
email: hworker77086600@yahoo.com.tw
台灣氫水實驗室部落格:http://blog.xuite.net/hworker77086600/twblog
歡迎來電索取氫水辨認方法(防止喝到傷身的假氫水)

提供玻璃瓶裝飽和氫水供對比，免費兩瓶給你測試，收運費120元。(運費是宅配業者收去的)